منابع مشابه
Essential Role of Na,k-atpase Α3 Essential Role of Na,k-atpase Α3 Essential Role of Na,k-atpase Α3 Essential Role of Na,k-atpase Α3 Essential Role of Na,k-atpase Α3
1 A specific and essential role for Na,K-ATPase α3 in neurons co-expressing α1 and α3* Background: Neurons express two Na,K-ATPase isoforms, the ubiquitous α1 and neuron-specific α3. Result: α3 is important for control of membrane potential and is fully responsible for restoration of large [Na + ] i increases. Conclusion: α1 and α3 are required for basal neuronal function, but α3 controls resto...
متن کاملCardiac glycosides and isoforms of Na/K-ATPase 1 Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase
There are four isoforms of the α subunit (α1-4) and three isoforms of the β subunit (β1-3) of Na,K-ATPase, with distinct tissue-specific distribution and physiological functions. α2 is thought to play a key role in cardiac and smooth muscle contraction and be an important target of cardiac glycosides. An α2selective cardiac glycoside could provide important insights into physiological and pharm...
متن کاملThe Na, K-ATPase in the failing human heart.
The Na, K-ATPase consists of alpha- and beta-subunits and actively transports Na out and K into the myocyte. It is the receptor for cardiac glycosides exerting its positive inotropic effect by inhibiting enzyme activity, decreasing the driving force for the Na/Ca-exchange and increasing cellular content and release of Ca during depolarization. The specific binding capacity for cardiac glycoside...
متن کاملNa,K-ATPase and epithelial tight junctions.
Tight junctions are unique organelles in polarized epithelial and endothelial cells that regulate the flow of solutes and ions across the epithelial barrier. The structure and functions of tight junctions are regulated by a wide variety of signaling and molecular mechanisms. Several recent studies in mammals, drosophila, and zebrafish reported a new role for Na,K-ATPase, a well-studied ion tran...
متن کاملMolecular activity of Na+/K+-ATPase
species in a predictable manner. For example, it is several-fold greater in endothermic than in ectothermic vertebrate species when measured at the same body temperature. This difference in metabolic activity appears to be primarily a cellular phenomenon, and it has recently been proposed that it is related to differences in membrane composition (Hulbert and Else, 1999, 2000). A substantial pro...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1989
ISSN: 0014-5793
DOI: 10.1016/0014-5793(89)81591-1